The victim was identified as Peggy Byrd, who lived in the house alone.
Rogersville Fire Department Chief David Jackson said the fire department was notified of a fire alarm at 1413 Chambers St. at 3:02 a.m., and firefighters arrived on the scene at 3:06 a.m.
"The alarm company called and said there was a fire alarm in the hallway, and when we arrived there was flames showing outside the building already," Jackson told the Times News. "I don't know how long it had been going, but it had been going more than four minutes. We made entry into the building, did a search, and did find one female who appeared to be deceased."
Jackson said it appeared that Byrd was attempting to exit the house when she succumbed.
He added, "It's easy for an elderly person to become disoriented in a fire situation with all the smoke, and with this fire there was heavy, heavy smoke damage."
The cause of the fire remains under investigation by Jackson, detectives from the Rogersville Police Department, and state fire marshal's office.
"We have determined an area of origin in the den, but we have not determined a cause or point of origin," Jackson said.
Volunteer firefighters from Lakeview and Striggersville assisted at the scene.